Gunasekaran Ramanthan
Professor, Kerala University of Health Science center
Title: Neurotrophic factors for the treatment of Motor neuron diseases (MNDs)
Biography
Biography: Gunasekaran Ramanthan
Abstract
Motor neuron diseases MNDs are a kind of neurodegenerative diseases, specifically it affects upper and lower motor neurons which cause motor signals unable to pass to the exact muscles. This leads uncontrollable twitching (fasciculations), gradual muscle weakening, wasting and paralysis. Yet there is no permanent cure for the MNDs. After disease on set within 3-4 years death occur. Still the therapeutic options limited, despite a large number of methods have been tested clinically. Neurotrophic factors treatments known to promote faster regeneration of motor neurons and CNS neurons have been reported. However, the exact neurotrophic factor not yet find out for clinical phase trials. In this we discuss the underlying principle behind those neurotrophic factors and neurotrophic factor drugs for treatment of MNDs